Zreik Riyam T, Meyer Reid G, Jenkins Robert B, Norambuena Germán A, Fritchie Karen J
Departments of *Laboratory Medicine and Pathology, and †Orthopedic Surgery, Mayo Clinic, Rochester, MN.
Am J Dermatopathol. 2016 Apr;38(4):e44-8. doi: 10.1097/DAD.0000000000000458.
Primary extraskeletal osteosarcoma is an exceedingly rare malignant neoplasm that accounts for approximately 1% of soft tissue sarcomas and most often occurs in the deep soft tissues of adults. Extraskeletal osteosarcoma is characterized by the production of osteoid, bone, and/or chondroid matrix. The diagnosis of extraskeletal osteosarcoma requires careful radiologic and clinical correlation to ensure that the patient does not have an underlying bone primary. This is a case report of primary subcutaneous extraskeletal osteosarcoma arising in the thigh of a 15-year-old girl with a complex karyotype, and the morphologic differential diagnosis is reviewed.
原发性骨外骨肉瘤是一种极其罕见的恶性肿瘤，约占软组织肉瘤的1%，最常发生于成人的深部软组织。骨外骨肉瘤的特征是产生类骨质、骨和/或软骨样基质。骨外骨肉瘤的诊断需要仔细的影像学和临床相关性分析，以确保患者没有潜在的骨原发性肿瘤。本文报告一例发生于一名15岁复杂核型女孩大腿的原发性皮下骨外骨肉瘤，并对其形态学鉴别诊断进行了综述。
