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器官移植受者中的恶性黑色素瘤:发病率、结局及管理策略:文献综述

Malignant melanoma in organ transplant recipients: incidence, outcomes, and management strategies: a review of literature.

作者信息

Džambová Martina, Sečníková Zuzana, Jiráková Anna, Jůzlová Kateřina, Viklický Ondřej, Hošková Lenka, Göpfertovà Dana, Hercogová Jana

机构信息

Department of Dermatology, 2nd Medical Faculty, Charles University in Prague and Bulovka Hospital, Prague, Czech Republic.

Department of Nephrology, Institute of Clinical and Experimental Medicine, Prague, Czech Republic.

出版信息

Dermatol Ther. 2016 Jan-Feb;29(1):64-8. doi: 10.1111/dth.12276. Epub 2015 Oct 13.

Abstract

Malignant melanoma is considered to be an immunogenic tumor, which is expected to change its behaviour in the field of immunosuppression. Although the incidence of melanoma in organ transplant recipients is increased to a smaller degree than in non-melanoma skin cancer, its potential morbidity and mortality has to be considered in the posttransplant care. The aim of this review is to investigate the relationship between melanoma and immunosuppression and to discuss management strategies for different melanoma scenarios in pre-transplant as well as posttransplant period.

摘要

恶性黑色素瘤被认为是一种免疫原性肿瘤,有望在免疫抑制领域改变其行为。尽管器官移植受者中黑色素瘤的发病率比非黑色素瘤皮肤癌的发病率升高程度较小,但在移植后护理中必须考虑其潜在的发病率和死亡率。本综述的目的是研究黑色素瘤与免疫抑制之间的关系,并讨论移植前以及移植后不同黑色素瘤情况的管理策略。

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