多胺对 Hedgehog 信号的影响

A Polyamine Twist on Hedgehog Signaling.

机构信息

Cancer Biology and Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Neurobiology, Harvard Medical School, Boston, MA 02115, USA.

出版信息

Dev Cell. 2015 Oct 12;35(1):1-2. doi: 10.1016/j.devcel.2015.09.024.

DOI:10.1016/j.devcel.2015.09.024

PMID:26460938

Abstract

The Hedgehog pathway plays important roles in embryonic development and oncogenesis, but how it affects metabolism is less clear. D'Amico et al. (2015) now demonstrate that the Hedgehog pathway regulates translation of ornithine decarboxylase, thereby enhancing polyamine biosynthesis and cell proliferation in neural precursor cells and in brain tumors.

摘要

Hedgehog 通路在胚胎发育和肿瘤发生中发挥重要作用，但它如何影响代谢尚不清楚。D'Amico 等人（2015 年）现在证明 Hedgehog 通路调节鸟氨酸脱羧酶的翻译，从而增强神经前体细胞和脑肿瘤中的多胺生物合成和细胞增殖。