当蛇失去四肢时，老鼠和蜥蜴说了什么？

When the Snake Lost Its Limbs, What Did the Mouse and Lizard Say?

机构信息

University of Cambridge, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge CB2 0RE, UK.

University of Cambridge, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge CB2 0RE, UK; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.

出版信息

Dev Cell. 2015 Oct 12;35(1):3-4. doi: 10.1016/j.devcel.2015.09.022.

DOI:10.1016/j.devcel.2015.09.022

PMID:26460939

Abstract

In this issue of Developmental Cell, Infante et al. (2015) compare regulatory DNA sequences in mice, lizards, and limbless snakes to reveal widespread sharing of enhancer activity in developing limbs and genitalia. Genetic deletion of a limb-genital enhancer demonstrates that common regulatory elements affect development of both appendages.

摘要

在本期《发育细胞》中，Infante 等人（2015）比较了小鼠、蜥蜴和无肢蛇的调控 DNA 序列，揭示了在发育中的四肢和生殖器中广泛存在的增强子活性共享。肢体-生殖器增强子的遗传缺失表明，常见的调控元件影响了两种附肢的发育。