Laboratoire de Biologie du Développement, CNRS-UMR7622, Institut de Biologie Paris-Seine, Université Pierre et Marie Curie, Sorbonne Universités, 75005 Paris, France.
Dev Cell. 2015 Oct 12;35(1):8-9. doi: 10.1016/j.devcel.2015.09.019.
Adherens junctions (AJs) play a crucial role in epithelial tissue development and tumorigenesis, and the mechanisms controlling their assembly and disassembly have therefore attracted considerable attention. A paper from Tsur et al. (2015) in this issue of Developmental Cell now shows how sumoylation and desumoylation of E-cadherin promotes its recruitment to AJs.
黏着连接（AJs）在上皮组织发育和肿瘤发生中起着至关重要的作用，因此控制其组装和拆卸的机制引起了相当大的关注。Tsur 等人在本期《发育细胞》杂志上的一篇论文表明，E-钙黏蛋白的 SUMO 化和去 SUMO 化如何促进其募集到 AJs。
