跳跃坑捕捉融合颗粒。

Hopping Pits Catch Fusing Granules.

机构信息

Leibniz Institut für Molekulare Pharmakologie (FMP), Robert-Roessle-Straße 10, 13125 Berlin, Germany.

出版信息

Dev Cell. 2015 Oct 12;35(1):10-1. doi: 10.1016/j.devcel.2015.09.026.

DOI:10.1016/j.devcel.2015.09.026

Abstract

In excitable cells, regulated exocytosis is coupled to endocytic membrane retrieval. Yuan et al. (2015) in this issue of Developmental Cell report a possible mechanism for such exo-endocytic coupling that is based on stimulation-induced hopping of clathrin-containing endocytic structures to nascent sites of insulin granule fusion.

摘要

在可兴奋细胞中，受调控的胞吐作用与内吞膜的回收相偶联。袁等人（2015）在本期《发育细胞》报告中提出了一种可能的外排-内摄偶联机制，该机制基于网格蛋白包被的内吞结构在刺激诱导下跳跃到新生的胰岛素颗粒融合部位。