Baniak Nick M, Kanthan Rani
University of Saskatchewan, Saskatoon, Saskatchewan, Canada
University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Int J Surg Pathol. 2016 Apr;24(2):146-52. doi: 10.1177/1066896915610817. Epub 2015 Oct 12.
A 59-year-old female received a matched related donor stem cell transplant for chronic myelogenous leukemia. After being successfully treated with prednisone for chronic graft versus host disease that initially started 50 days posttransplant, she developed hepatic dysfunction during the steroid taper on day 531, as evidenced by jaundice, elevated liver enzymes, and increased bilirubin. Liver biopsy showed histology suggestive of autoimmune-like hepatitis, which is a rare manifestation of chronic "hepatitic" graft versus host disease.
一名59岁女性因慢性粒细胞白血病接受了匹配的相关供体干细胞移植。在移植后50天开始出现慢性移植物抗宿主病并成功接受泼尼松治疗后，她在第531天逐渐减少类固醇用量期间出现肝功能障碍，表现为黄疸、肝酶升高和胆红素增加。肝脏活检显示组织学提示自身免疫样肝炎，这是慢性“肝炎性”移植物抗宿主病的一种罕见表现。
