Barone G W, Conerly J M, Farley P C, Flanagan T L, Kron I L
Department of Surgery, University of Virginia Medical Center, Charlottesville 22908.
J Vasc Surg. 1989 Mar;9(3):422-5. doi: 10.1067/mva.1989.vs0090422.
Endothelial-derived relaxing factor is an important modulator of vascular relaxation, and its production is very sensitive to endothelial injury. The abdominal aortas of five groups of rabbits were subjected to Fogarty balloon catheterization via the femoral artery. Some rabbits were killed immediately (time 0), and others were killed at weekly intervals. At time 0, isolated vascular rings sectioned from the abdominal aortas and suspended in tissue baths failed to exhibit any endothelial-derived relaxing factor dependent vascular relaxation. Vascular relaxation progressively returned but was not normal until 4 weeks after the initial injury. Morphologic changes studied by means of Evans blue dye and by scanning electron microscopy with silver staining corresponded well with these functional changes. At time 0, the delicate endothelium was completely denuded, but it progressively regenerated over the subsequent 4 weeks. This severe injury to the vascular endothelium and the resultant vascular dysfunction may result in an increased risk of early postoperative spasm and thrombosis after the use of a Fogarty balloon catheter.
内皮源性舒张因子是血管舒张的重要调节因子，其生成对内皮损伤非常敏感。通过股动脉对五组家兔的腹主动脉进行Fogarty球囊导管插入术。一些家兔立即处死（0时刻），其他家兔每隔一周处死。在0时刻，从腹主动脉切下并悬浮于组织浴中的离体血管环未表现出任何依赖内皮源性舒张因子的血管舒张。血管舒张逐渐恢复，但直到初次损伤后4周才恢复正常。通过伊文思蓝染料以及银染扫描电子显微镜研究的形态学变化与这些功能变化非常吻合。在0时刻，纤细的内皮完全剥脱，但在随后4周内逐渐再生。这种对血管内皮的严重损伤以及由此导致的血管功能障碍可能会增加使用Fogarty球囊导管后早期术后痉挛和血栓形成的风险。
