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New Approach about the Signaling Crosstalk between IQGAPs/ NF- κB/IL-8 and PDCD5/p53/TRAIL Pathways that Modulate Malignant Transformation in Hepatocellular Carcinoma.关于 IQGAPs/NF-κB/IL-8 和 PDCD5/p53/TRAIL 通路在调控肝癌恶性转化中的信号串扰的新方法。
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Scaffolding Protein IQGAP1 Is Dispensable, but Its Overexpression Promotes Hepatocellular Carcinoma via YAP1 Signaling.支架蛋白 IQGAP1 不可或缺，但过表达通过 YAP1 信号促进肝细胞癌。
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本文引用的文献

1
Hedgehog signaling blockade delays hepatocarcinogenesis induced by hepatitis B virus X protein.Hedgehog 信号通路阻断可延缓乙型肝炎病毒 X 蛋白诱导的肝癌发生。
Cancer Res. 2012 Nov 15;72(22):5912-20. doi: 10.1158/0008-5472.CAN-12-2329. Epub 2012 Sep 17.
2
Watch the GAP: Emerging Roles for IQ Motif-Containing GTPase-Activating Proteins IQGAPs in Hepatocellular Carcinoma.关注差距：含IQ模体的GTP酶激活蛋白IQGAPs在肝细胞癌中的新作用
Int J Hepatol. 2012;2012:958673. doi: 10.1155/2012/958673. Epub 2012 Sep 3.
3
IQGAP1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation by Akt activation.IQGAP1 在肝细胞癌中过表达，并通过 Akt 激活促进细胞增殖。
Exp Mol Med. 2010 Jul 31;42(7):477-83. doi: 10.3858/emm.2010.42.7.049.
4
IQGAPs in cancer: a family of scaffold proteins underlying tumorigenesis.癌症中的IQGAPs：一类参与肿瘤发生的支架蛋白家族。
FEBS Lett. 2009 Jun 18;583(12):1817-24. doi: 10.1016/j.febslet.2009.05.007. Epub 2009 May 9.
5
IQGAP1 regulation and roles in cancer.IQGAP1在癌症中的调控作用
Cell Signal. 2009 Oct;21(10):1471-8. doi: 10.1016/j.cellsig.2009.02.023. Epub 2009 Mar 6.
6
Quantitative proteomic analysis of HepG2 cells treated with quercetin suggests IQGAP1 involved in quercetin-induced regulation of cell proliferation and migration.槲皮素处理 HepG2 细胞的定量蛋白质组学分析表明，IQGAP1 参与了槲皮素诱导的细胞增殖和迁移的调节。
OMICS. 2009 Apr;13(2):93-103. doi: 10.1089/omi.2008.0075.
7
IQGAP1-dependent signaling pathway regulates endothelial cell proliferation and angiogenesis.依赖IQGAP1的信号通路调节内皮细胞增殖和血管生成。
PLoS One. 2008;3(12):e3848. doi: 10.1371/journal.pone.0003848. Epub 2008 Dec 3.
8
Multitargeted cancer prevention by quercetin.槲皮素的多靶点癌症预防作用
Cancer Lett. 2008 Oct 8;269(2):315-25. doi: 10.1016/j.canlet.2008.03.046. Epub 2008 May 7.
9
Mouse model of diethylnitrosamine-induced gastric cancer.二乙基亚硝胺诱导的胃癌小鼠模型
J Surg Res. 2008 Aug;148(2):152-7. doi: 10.1016/j.jss.2007.12.748. Epub 2008 Jan 10.
10
A dual role for IQGAP1 in regulating exocytosis.IQGAP1在调节胞吐作用中的双重作用。
J Cell Sci. 2008 Feb 1;121(Pt 3):391-403. doi: 10.1242/jcs.016881.

IQGAPs和Ras家族在肝细胞癌实验小鼠模型中的基因表达：癌症进展的机制研究

Gene expression of IQGAPs and Ras families in an experimental mouse model for hepatocellular carcinoma: a mechanistic study of cancer progression.

作者信息

Zoheir Khairy M A, Abd-Rabou Ahmed A, Harisa Gamaleldin I, Ashour Abdelkader E, Ahmad Sheikh Fayaz, Attia Sabry M, Bakheet Saleh A, Abdel-Hamied Hala E, Abd-Allah Adel R, Kumar Ashok

机构信息

Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University P.O. Box 2457, Riyadh, Saudi Arabia ; Department of Cell Biology, National Research Centre (12622) Cairo, Egypt.

Department of Hormones, Medical Research Division, National Research Centre (12622) Cairo, Egypt.

出版信息

Int J Clin Exp Pathol. 2015 Aug 1;8(8):8821-31. eCollection 2015.

PMID:26464624
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4583856/
Abstract

IQGAPs genes play critical role in either induction or suppression of cancer and its progression, however the relationship between Ras genes and these genes are still unclear. In this study, we tried to understand the mechanistic action of IQGAPs genes and its correlation with Ras genes in mouse hepatic cancer model. The genetic expressions of IQGAP1, IQGAP2, IQGAP3, Hras, Kras, Nras, Mras, Caspase3, and BAX were followed in both hepatocellular carcinoma and normal liver cells of Balbc mice. Genotoxic agent diethylnitrosamine (DEN)-induced hepatic cancer model was induced in male mice and recorded the occurrence of hepatocellular carcinoma by morphological and histological changes in the liver. It was observed that mRNA expressions of IQGAP1, Hras, Kras, Nras, Mras, Caspase3, and BAX genes were highly elevated in hepatocellular carcinoma cells when compared with normal liver cells, additionally their expressions increased by concentrating the dose of DEN. While, the expressions of IQGAP2 and IQGAP3 were significantly decreased in hepatocellular carcinoma cells when compared with normal liver cells, as well as their expressions decreased more with increasing the dose of DEN. It was concluded from this study that IQGAP1 has a strong signaling relationship with Ras genes in induction of cancer and it is considered as a key gene for induction or suppression of the hepatocellular carcinoma.

摘要

IQGAPs基因在癌症的诱导或抑制及其进展中发挥着关键作用，然而Ras基因与这些基因之间的关系仍不清楚。在本研究中，我们试图了解IQGAPs基因在小鼠肝癌模型中的作用机制及其与Ras基因的相关性。在Balbc小鼠的肝细胞癌和正常肝细胞中追踪IQGAP1、IQGAP2、IQGAP3、Hras、Kras、Nras、Mras、Caspase3和BAX的基因表达。用基因毒性剂二乙基亚硝胺（DEN）诱导雄性小鼠建立肝癌模型，并通过肝脏的形态学和组织学变化记录肝细胞癌的发生情况。观察到与正常肝细胞相比，IQGAP1、Hras、Kras、Nras、Mras、Caspase3和BAX基因的mRNA表达在肝癌细胞中高度升高，此外，随着DEN剂量的增加，它们的表达也增加。而与正常肝细胞相比，IQGAP2和IQGAP3在肝癌细胞中的表达显著降低，并且随着DEN剂量的增加，它们的表达降低得更多。本研究得出结论，IQGAP1在癌症诱导中与Ras基因有很强的信号关系，并且它被认为是诱导或抑制肝细胞癌的关键基因。