Kobayashi H, Endo K, Nishimura K, Kasagi K, Yamamoto I, Konishi J, Abe M, Shimizu Y
Dept. of Radiology and Nuclear Medicine, Kyoto Univ. School of Med.
Gan No Rinsho. 1989 Jan;35(1):55-62.
Bone metastasis from a thyroid papillary cancer of a 59-year-old woman had been successfully treated with radiotherapy (6,000 rad) and iodine-131 (120 mCi). One year later, the patient developed leukocytosis (maximum 143,000/mm3) and hypercalcemia (16.0 mg/dl). A colony stimulating factor (CSF) was detectable in her plasma, and nude mice that had been given metastatic tissues similarly developed leukocytosis and hypercalcemia. Leukocytosis and hypercalcemia seemed to have been caused by the CSF produced in the bone metastasized tissues of this thyroid cancer.
