Tajima Shogo
Department of Pathology, Shizuoka Saiseikai General Hospital Shizuoka, Japan ; Department of Pathology, Fujieda Municipal General Hospital Shizuoka, Japan ; Department of Pathology, Graduate School of Medicine, The University of Tokyo Tokyo, Japan.
Int J Clin Exp Pathol. 2015 Aug 1;8(8):9638-42. eCollection 2015.
Various histological variants of urothelial carcinoma (UC) have been described. They are associated with different clinical outcomes and/or therapeutic approaches; in addition, recognition of these histological variants is also important in preventing diagnostic misinterpretations. Histological variants based on cytoplasmic features, such as plasmacytoid, rhabdoid, clear-cell, and lipoid-rich variants, have been described in invasive UC. Herein, we report an exceedingly rare case of a rhabdoid variant of UC arising in the urinary bladder of a 61-year-old man. Including UC, the presence of rhabdoid cells has been described in various types of malignant tumors. These tumors are regarded as more aggressive neoplasms than those without rhabdoid cells. It has been previously found that non-degraded aggregation of intermediate filaments and membrane proteins conjugated with ubiquitin and p62 is a noticeable finding in the formation of rhabdoid morphology. We have validated the existence of this mechanism in a rhabdoid variant of UC by extensive immunohistochemical analysis.
尿路上皮癌（UC）的多种组织学变体已被描述。它们与不同的临床结果和/或治疗方法相关；此外，识别这些组织学变体对于防止诊断误解也很重要。基于细胞质特征的组织学变体，如浆细胞样、横纹肌样、透明细胞和富含脂质的变体，已在浸润性UC中被描述。在此，我们报告了一例极为罕见的发生在一名61岁男性膀胱的UC横纹肌样变体病例。包括UC在内，横纹肌样细胞已在各种类型的恶性肿瘤中被描述。这些肿瘤被认为比没有横纹肌样细胞的肿瘤更具侵袭性。先前已发现中间丝和与泛素及p62结合的膜蛋白的非降解聚集是形成横纹肌样形态的一个显著特征。我们通过广泛的免疫组化分析验证了这种机制在UC横纹肌样变体中的存在。
