He Du, Chen Min, Chen Huijiao, Liao Dianying, Wang Xiaozhou, Zhang Zhang, Zhang Hongying
Department of Pathology, West China Hospital, Sichuan University Chengdu, Sichuan, China.
Department of Radiology, Meishan City People's Hospital Meishan, Sichuan, China.
Int J Clin Exp Pathol. 2015 Aug 1;8(8):9662-6. eCollection 2015.
Liposarcoma originating in the heart is extraordinarily rare. Herein, we report a dedifferentiated liposarcoma arising from the left atrium in a 59-year-old Chinese man. Histologically, the neoplasm predominantly consisted of undifferentiated pleomorphic sarcoma. In addition, the neoplasm exhibited lipoblastic differentiation and osteo-/chondrosarcomatous components. Immunohistochemically, the neoplastic cells were strongly positive for p16, MDM2, and CDK4. Fluorescence in situ hybridization showed MDM2 gene amplification in all of the tumor components. To the best of our knowledge, this is the first published example of cardiac dedifferentiated liposarcoma exhibiting homologous and heterologous differentiation without a well-differentiated liposarcoma component.
起源于心脏的脂肪肉瘤极为罕见。在此，我们报告一例发生于一名59岁中国男性左心房的去分化脂肪肉瘤。组织学上，该肿瘤主要由未分化多形性肉瘤组成。此外，肿瘤呈现脂肪母细胞分化以及骨肉瘤/软骨肉瘤成分。免疫组化显示，肿瘤细胞对p16、MDM2和CDK4呈强阳性。荧光原位杂交显示所有肿瘤成分均有MDM2基因扩增。据我们所知，这是首次发表的心脏去分化脂肪肉瘤病例，其表现为同源和异源分化，且无高分化脂肪肉瘤成分。
