Wang Hui, Xie Jun, Tan Yan, Jiang Jingting
Department of Pathology, The Third Affiliated Hospital of Soochow University 185 Juqian Street, Changzhou 213003, P. R. China.
Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University Changzhou 213003, P. R. China.
Int J Clin Exp Pathol. 2015 Aug 1;8(8):9723-6. eCollection 2015.
A tracheal glomus tumor is extremely rare. There were approximately 18 reported cases before in China. Here we report a 48-year-old male with glomus tumor of the trachea. The computed tomography (CT) scan of the chest showed a nodulein the basalsegmentof right lower lobe, focal uplift in the left-posterior wall of the trachea, measured 1.5×1.2×1.0 cm. Microscopically, the tumor tissue was rich with vessels, shaped flake-nest, and the tumor consisted of a sheet of uniform cells surrounding the vascular spaces. Immumohistochemical staining were positive for SMA, vimentin, collagen IV, CD34, the Ki-67 proliferation activity was low (<1%), and were negative for Syn, CgA, S-100, AE1/AE3 and EMA. PSA staining showing clear cell borders. With a review of the literature, the clinical, pathological characteristics and treatment modalities of this rare tumor are discussed.
气管球瘤极为罕见。此前中国国内报道的病例约有18例。在此，我们报告1例48岁男性气管球瘤患者。胸部计算机断层扫描（CT）显示右下叶基底段有一个结节，气管左后壁有局灶性隆起，大小为1.5×1.2×1.0 cm。显微镜下，肿瘤组织血管丰富，呈片状巢状，肿瘤由围绕血管间隙的一层均匀细胞组成。免疫组化染色显示平滑肌肌动蛋白（SMA）、波形蛋白、IV型胶原、CD34呈阳性，Ki-67增殖活性低（<1%），而突触素（Syn）、嗜铬粒蛋白A（CgA）、S-100、AE1/AE3和上皮膜抗原（EMA）呈阴性。前列腺特异性抗原（PSA）染色显示细胞边界清晰。通过文献复习，对这种罕见肿瘤的临床、病理特征及治疗方式进行了讨论。
