四氯化锡促进的1,1-二取代烯丙基醚的串联C-O键裂解/纳扎罗夫环化/亲核加成反应用于多取代茚的合成
A Tin(IV) Chloride Promoted Tandem C-O Bond Cleavage/Nazarov Cyclization/Nucleophilic Addition Reaction of 1,1-Disubstituted Allylic Ethers toward the Synthesis of Multisubstituted Indenes.
作者信息
Yang Chao, Xu Zheng-Liang, Shao Hui, Mou Xue-Qing, Wang Jie, Wang Shao-Hua
机构信息
School of Pharmacy & State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, P. R. China.
Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, Sichuan University , Chengdu, P. R. China.
出版信息
Org Lett. 2015 Nov 6;17(21):5288-91. doi: 10.1021/acs.orglett.5b02610. Epub 2015 Oct 14.
A novel SnCl4-promoted tandem reaction toward multisubstituted indenes via a sequential C-O bond cleavage/Nazarov cyclization/nucleophilic addition reaction has been developed to afford a series of multisubstituted indenes with an all-carbon quaternary center in moderate to good yields.
已开发出一种新型的由四氯化锡促进的串联反应，通过连续的碳 - 氧键断裂/纳扎罗夫环化/亲核加成反应生成多取代茚，以中等至良好的产率得到一系列具有全碳季碳中心的多取代茚。
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