Hnátek Lukáš
Vnitr Lek. 2015 Sep;61(9):807-14.
Chronic venous disorder (CVD) is a common illness with high incidence existing especially in Europe and North America. The main goal of micronized purified flavonoid fraction (MPFF) of diosmin and hesperidin is to eliminate the symptoms of CVD (venous pain, fatigue, etc). But MPFF of diosmin and hesperidin has good effectiveness for treatment of venous oedema and venous ulcer too. There are many papers that prove its effectiveness in the experiment and in the microcirculation too. The other indications for MPFF of diosmin hesperidin is hemorrhoidal disease and the accessory treatment of lymphedema. It is proved that this substance could be used as an effective supplementary treatment of symptoms after venous intervention. Only MPFF diosmin and hesperidin received the best recommendation - 1B in the last guidelines for VAD therapy.
慢性静脉疾病（CVD）是一种常见疾病，发病率很高，尤其在欧洲和北美地区。地奥司明和橙皮苷微粉化纯化黄酮组分（MPFF）的主要目标是消除CVD的症状（静脉疼痛、疲劳等）。但地奥司明和橙皮苷的MPFF对治疗静脉水肿和静脉溃疡也有良好疗效。有许多论文证明了其在实验和微循环中的有效性。地奥司明橙皮苷MPFF的其他适应症是痔疮疾病和淋巴水肿的辅助治疗。事实证明，这种物质可作为静脉介入术后症状的有效辅助治疗。在最新的VAD治疗指南中，只有地奥司明和橙皮苷MPFF获得了最佳推荐——1B级。
