Fett Anne-Kathrin J, González Berdugo Clara Isabel, Hanssen Esther, Lemmers-Jansen Imke, Shergill Sukhi S, Krabbendam Lydia
a Department of Educational Neuroscience and LEARN! Research Institute for Learning and Education, Faculty of Behavioural and Movement Sciences , VU University Amsterdam , Van der Boechorststraat 1, Amsterdam 1081 BT , The Netherlands.
b Department of Psychosis Studies , Institute of Psychiatry, Psychology and Neuroscience, King's College London , De Crespigny Park, London SE5 8AF , UK.
Cogn Neuropsychiatry. 2015;20(6):473-81. doi: 10.1080/13546805.2015.1088824. Epub 2015 Oct 14.
Paranoid delusions have been associated with a tendency to over-attribute intentionality and contingency to others' actions and incidental events in individuals with chronic psychosis. However, this hyper-associative perception bias has not been investigated in the early illness stages of psychosis, during which it may play a particularly crucial role in the formation of symptoms.
We used an experimental paradigm with 20 short film clips of simple animate and inanimate shapes that either moved in a contingent or non-contingent manner to investigate the perception of contingency in 38 adolescents with early psychosis and 93 healthy control adolescents. Participants rated the contingency between the shapes' movements on a scale from 0 to 10. The data were analysed with multilevel regression analyses to account for repeated measures within subjects.
There were no significant differences between patients and controls; both perceived the contingency of the shapes' movements similarly across all conditions and patients' contingency perception was unrelated to their levels of paranoid delusions.
Contingency perception was unimpaired in patients with early psychosis, suggesting that it might still be intact in the early illness stages. Future studies should set out to determine whether the early illness stages could offer a window for interventions that counteract the development of hyper-associative perceptions of contingency.
在慢性精神病患者中，偏执妄想与倾向于过度将他人行为和偶然事件的意图性和偶然性归因于此有关。然而，这种过度联想的感知偏差在精神病的早期阶段尚未得到研究，而在这一阶段它可能在症状形成中发挥特别关键的作用。
我们使用了一个实验范式，包含20个简单的有生命和无生命形状的短片剪辑，这些形状以偶然或非偶然的方式移动，以研究38名早期精神病青少年和93名健康对照青少年对偶然性的感知。参与者对形状运动之间的偶然性在0到10的量表上进行评分。数据采用多级回归分析进行分析，以考虑受试者内的重复测量。
患者和对照组之间没有显著差异；在所有条件下，双方对形状运动的偶然性感知相似，并且患者的偶然性感知与他们的偏执妄想水平无关。
早期精神病患者的偶然性感知未受损，这表明在疾病早期阶段它可能仍然完好无损。未来的研究应着手确定疾病早期阶段是否可以为干预措施提供一个窗口，以对抗对偶然性的过度联想感知的发展。
