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泊肃叶流中红细胞非惯性聚焦的预测。

Prediction of noninertial focusing of red blood cells in Poiseuille flow.

作者信息

Hariprasad Daniel S, Secomb Timothy W

机构信息

Department of Chemical and Biological Engineering, The University of New Mexico, Albuquerque, New Mexico 87131, USA.

Department of Physiology, University of Arizona, Tucson, Arizona 85721, USA.

出版信息

Phys Rev E Stat Nonlin Soft Matter Phys. 2015 Sep;92(3):033008. doi: 10.1103/PhysRevE.92.033008. Epub 2015 Sep 9.

Abstract

The motions of a red blood cell in Poiseuille flows in a range of channel widths are simulated using a two-dimensional model. For a range of initial off-centerline distances in a 12-μm channel, cell trajectories converge to a specific off-centerline position and exhibit tank-treading motions. This behavior coexists with initial positions that lead to migration towards the centerline. The predicted off-centerline focusing effect is shown to depend on the curvature of the flow profile and on interactions with both solid boundaries.

摘要

使用二维模型模拟了红细胞在一系列通道宽度的泊肃叶流中的运动。对于12微米通道内一系列初始偏离中心线的距离,细胞轨迹会收敛到特定的偏离中心线位置并呈现坦克履带式运动。这种行为与导致向中心线迁移的初始位置共存。预测的偏离中心线聚焦效应表明取决于流动剖面的曲率以及与两个固体边界的相互作用。

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