FB Chemie-Organische Chemie, Technische Universität Kaiserslautern, Erwin-Schrödinger-Strasse Geb. 54, 67663 Kaiserslautern (Germany).
Angew Chem Int Ed Engl. 2015 Oct 19;54(43):12607-11. doi: 10.1002/anie.201505769. Epub 2015 Sep 3.
In the presence of catalytic [{IrCp*Cl2 }2 ] and Ag2 CO3 , Li2 CO3 as the base, and acetone as the solvent, benzoic acids react with arenediazonium salts to give the corresponding diaryl-2-carboxylates under mild conditions. This C-H arylation process is generally applicable to diversely substituted substrates, ranging from extremely electron-rich to electron-poor derivatives. The carboxylate directing group is widely available and can be removed tracelessly or employed for further derivatization. Orthogonality to halide-based cross-couplings is achieved by the use of diazonium salts, which can be coupled even in the presence of iodo substituents.
在催化 [{IrCp*Cl2 }2 ] 和 Ag2 CO3 的存在下，以 Li2 CO3 作为碱，以丙酮作为溶剂，苯甲酸与芳基重氮盐反应，在温和条件下得到相应的二芳基-2-羧酸酯。这个 C-H 芳基化过程通常适用于各种取代的底物，从极富电子到缺电子的衍生物。羧酸酯导向基团广泛存在，可以无痕迹地去除或用于进一步的衍生化。通过使用重氮盐，可以实现与卤代物交叉偶联的正交性，即使存在碘取代基也可以进行偶联。
