一种新型前列腺素是兔心脏中花生四烯酸代谢的主要产物。
A novel prostaglandin is the major product of arachidonic acid metabolism in rabbit heart.
作者信息
Isakson P C, Raz A, Denny S E, Pure E, Needleman P
出版信息
Proc Natl Acad Sci U S A. 1977 Jan;74(1):101-5. doi: 10.1073/pnas.74.1.101.
Abstract
The prostaglandins (PGs) released from the heart have generally been characterized as resembling PGE by bioassay techniques. The major PG formed from [14C]arachidonate (C20:4) by the isolated perfused rabbit heart has chromatographic mobility similar to that of PGE2 in most solvent systems. However, additional analysis of this radioactive "PGE" peak suggests that two substances are formed by the heart and migrate like PGE2: one has chemical properties similar to those of authentic PGE2 and the other is a novel PG. The unknown compound is the major PG formed by the heart from either exogenous arachidonate or hormonal stimulation of PG biosynthesis. The novel PG produced by the heart may be identical with either 6(9)-oxy-PGF or 6-keto-PGF1 alpha.
摘要
心脏释放的前列腺素（PGs）通常通过生物测定技术被鉴定为类似于前列腺素E（PGE）。在大多数溶剂系统中，离体灌注兔心脏由[14C]花生四烯酸（C20:4）形成的主要PG具有与PGE2相似的色谱迁移率。然而，对这个放射性“PGE”峰的进一步分析表明，心脏形成了两种物质，它们的迁移方式与PGE2相似：一种具有与 authentic PGE2相似的化学性质，另一种是新型PG。未知化合物是心脏由外源性花生四烯酸或PG生物合成的激素刺激形成的主要PG。心脏产生的新型PG可能与6(9)-氧代-PGF或6-酮-PGF1α相同。
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