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心肌梗死后非罪犯血管的血流储备分数：它可靠吗？

Fractional flow reserve of non-culprit vessel post-myocardial infarction: is it reliable?

作者信息

Leite Luís, Moura Ferreira Joana, Silva Marques João, Jorge Elisabete, Matos Vítor, Guardado Jorge, Calisto João, Pego Mariano

机构信息

Departament of Cardiology, Centro Hospitalar e Universitário de Coimbra, Praceta Prof. Mota Pinto, Coimbra, 3000-075, Portugal.

出版信息

BMC Cardiovasc Disord. 2015 Oct 14;15:127. doi: 10.1186/s12872-015-0122-1.

DOI:10.1186/s12872-015-0122-1
PMID:26467002
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4606848/
Abstract

BACKGROUND

Multi-vessel disease is frequent in patients presenting with myocardial infarction and have an important prognostic impact. The decision to proceed to revascularization in non-culprit vessels can be postponed until ischemia is proven in non-invasive stress tests. On the other hand, there is an increasing evidence to support the role of fractional flow reserve (FFR) in acute coronary syndrome setting.

CASE PRESENTATION

We report a case in which a FFR-guided strategy for non-culprit vessels, 3 weeks after an ST-segment elevation myocardial infarction, was followed by a short-term sub-occlusion of the evaluated vessel.

CONCLUSION

The timing of the coronary microcirculation recovery post-myocardial infarction, avoiding a possible false negative FFR, and the diagnostic gaps between ischemia and plaque vulnerability are under discussion. An FFR-guided strategy in this setting should be interpreted with caution.

摘要

背景

多支血管病变在心肌梗死患者中很常见，且对预后有重要影响。对于非罪犯血管进行血运重建的决定可推迟到无创负荷试验证实有缺血时。另一方面，越来越多的证据支持血流储备分数（FFR）在急性冠状动脉综合征中的作用。

病例报告

我们报告了一例病例，在ST段抬高型心肌梗死后3周，对非罪犯血管采用FFR指导策略，随后评估血管出现短期次全闭塞。

结论

心肌梗死后冠状动脉微循环恢复的时机、避免可能出现的FFR假阴性以及缺血与斑块易损性之间的诊断差距仍在讨论中。在这种情况下，FFR指导策略应谨慎解读。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dda4/4606848/b6333fee5ad0/12872_2015_122_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dda4/4606848/2aca6d25cfe2/12872_2015_122_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dda4/4606848/03dbbb2388c5/12872_2015_122_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dda4/4606848/b6333fee5ad0/12872_2015_122_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dda4/4606848/2aca6d25cfe2/12872_2015_122_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dda4/4606848/03dbbb2388c5/12872_2015_122_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dda4/4606848/b6333fee5ad0/12872_2015_122_Fig3_HTML.jpg

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本文引用的文献

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Int J Cardiol. 2015;187:33-8. doi: 10.1016/j.ijcard.2015.03.316. Epub 2015 Mar 21.
2
Impact of microvascular obstruction on the assessment of coronary flow reserve, index of microcirculatory resistance, and fractional flow reserve after ST-segment elevation myocardial infarction.微血管阻塞对 ST 段抬高型心肌梗死患者冠状动脉血流储备、微血管阻力指数和血流储备分数评估的影响。
J Am Coll Cardiol. 2014 Nov 4;64(18):1894-904. doi: 10.1016/j.jacc.2014.07.987. Epub 2014 Oct 27.
3
Fractional flow reserve and the index of microvascular resistance in patients with acute coronary syndromes.
急性冠状动脉综合征患者的血流储备分数与微血管阻力指数
EuroIntervention. 2014 Aug;10 Suppl T:T55-63. doi: 10.4244/EIJV10STA10.
4
2014 ESC/EACTS Guidelines on myocardial revascularization: The Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)Developed with the special contribution of the European Association of Percutaneous Cardiovascular Interventions (EAPCI).2014年欧洲心脏病学会/欧洲心胸外科学会心肌血运重建指南：欧洲心脏病学会（ESC）和欧洲心胸外科学会（EACTS）心肌血运重建特别工作组编写，欧洲经皮心血管介入协会（EAPCI）提供特别贡献。
Eur Heart J. 2014 Oct 1;35(37):2541-619. doi: 10.1093/eurheartj/ehu278. Epub 2014 Aug 29.
5
Clinical and angiographic characteristics of patients likely to have vulnerable plaques: analysis from the PROSPECT study.可能存在易损斑块患者的临床和血管造影特征：来自 PROSPECT 研究的分析。
JACC Cardiovasc Imaging. 2013 Dec;6(12):1263-72. doi: 10.1016/j.jcmg.2013.04.015. Epub 2013 Oct 23.
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Am J Cardiol. 2012 Aug 15;110(4):471-7. doi: 10.1016/j.amjcard.2012.04.018. Epub 2012 May 11.
10
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