新生儿高胆红素血症与UGT1A1基因多态性的关联：一项荟萃分析
Association of Neonatal Hyperbilirubinemia with UGT1A1 Gene Polymorphisms: A Meta-Analysis.
作者信息
Yu Zibi, Zhu Kaichang, Wang Li, Liu Ying, Sun Jianmei
机构信息
Songjiang Branch of The Affiliated Shuguang Hospital of Shanghai University of TCM, Shanghai, China (mainland).
Department of Urology, Fengxian District Central Hospital, Shanghai, China (mainland).
出版信息
Med Sci Monit. 2015 Oct 15;21:3104-14. doi: 10.12659/msm.894043.
BACKGROUND
The results of studies on association between the polymorphisms in the coding region and the promoter of uridine diphosphateglucuronosyl transferase 1A1 (UGT1A1) and neonatal hyperbilirubinemia are controversial. This study aimed to determine whether the UGT1A1 gene polymorphisms of Gly71Arg and TATA promoter were significant risk factors associated with neonatal hyperbilirubinemia.
MATERIAL AND METHODS
The PubMed, Cochrane Library, and Embase databases were searched for papers that describe the association between UGT1A1 polymorphisms and neonatal hyperbilirubinemia. Summary odds ratios and 95% confidence intervals (CI) were estimated based on a fixed-effects model or random-effects model, depending on the absence or presence of significant heterogeneity.
RESULTS
A total of 32 eligible studies and 6520 participants were identified. Among them, 24 studies focused on the association of neonatal hyperbilirubinemia with UGT1A1 Gly71Arg polymorphisms, and a significant difference was found for the comparison of AA vs. AG+GG (OR=3.47, 95% CI=2.29-5.28, P<0.0001). We included 19 studies on the association of neonatal hyperbilirubinemia with UGT1A1 TATA promoter polymorphism, which also found a statistically significant difference between 7/7 and 6/7 + 6/6 (OR=2.24, 95% CI=1.29-3.92, P=0.004).
CONCLUSIONS
This meta-analysis demonstrated that UGT1A1 polymorphisms (Gly71Arg and TATA promoter) significantly increase the risk of neonatal hyperbilirubinemia.
背景
关于尿苷二磷酸葡萄糖醛酸基转移酶1A1（UGT1A1）编码区和启动子多态性与新生儿高胆红素血症之间关联的研究结果存在争议。本研究旨在确定UGT1A1基因Gly71Arg多态性和TATA启动子是否为新生儿高胆红素血症的显著危险因素。
材料与方法
检索PubMed、Cochrane图书馆和Embase数据库，查找描述UGT1A1多态性与新生儿高胆红素血症之间关联的论文。根据是否存在显著异质性，基于固定效应模型或随机效应模型估计汇总比值比和95%置信区间（CI）。
结果
共纳入32项符合条件的研究和6520名参与者。其中，24项研究聚焦于新生儿高胆红素血症与UGT1A1 Gly71Arg多态性的关联，发现AA与AG + GG比较存在显著差异（OR = 3.47，95% CI = 2.29 - 5.28，P < 0.0001）。我们纳入了19项关于新生儿高胆红素血症与UGT1A1 TATA启动子多态性关联的研究，也发现7/7与6/7 + 6/6之间存在统计学显著差异（OR = 2.24，95% CI = 1.29 - 3.92，P = 0.004）。
结论
这项荟萃分析表明，UGT1A1多态性（Gly71Arg和TATA启动子）显著增加新生儿高胆红素血症的风险。
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