Solmaz U, Mat E, Dereli M L, Turan V, Ekin A, Tosun G, Dogan A, Ozdemir I A, Oztekin O, Sanci M
a Department of Gynecologic Oncology , Tepecik Training and Research Hospital , Izmir , Turkey.
b Department of Obstetrics and Gynecology , Tavas State Hospital , Denizli , Turkey.
J Obstet Gynaecol. 2016;36(1):81-6. doi: 10.3109/01443615.2015.1041890. Epub 2015 Oct 14.
The objective of this study was to evaluate the clinicopathological characteristics, treatment and prognosis of advanced endometrial cancer (EC). Patients who underwent surgery for advanced EC between January 1995 and December 2012 were retrospectively reviewed. Patients with missing data, concurrent cancers or uterine sarcomas and those who did not undergo surgery were excluded. The effects of clinicopathological factors on progression-free survival (PFS) and overall survival (OS) were analyzed. A total of 104 patients were included. Most presented with endometrioid histology (74%) and stage-III disease (87.5%), and 76.9% underwent optimal cytoreduction. A multivariate analysis confirmed that lymphovascular space invasion (LVSI) is an independent poor prognostic factor for PFS [odds ratio (OR): 21.37, p = 0.005] and OS [OR: 8.09, p = 0.044]. Suboptimal cytoreduction is another independent poor prognostic factor for PFS [OR: 5.68, p < 0.001]. Our study demonstrated that LVSI and optimal cytoreduction are the most significant factors affecting the survival of advanced EC patients.
本研究的目的是评估晚期子宫内膜癌（EC）的临床病理特征、治疗及预后。对1995年1月至2012年12月期间接受晚期EC手术的患者进行回顾性分析。排除数据缺失、合并其他癌症或子宫肉瘤以及未接受手术的患者。分析临床病理因素对无进展生存期（PFS）和总生存期（OS）的影响。共纳入104例患者。大多数患者为子宫内膜样组织学类型（74%）和Ⅲ期疾病（87.5%），76.9%的患者接受了最佳细胞减灭术。多因素分析证实，淋巴管间隙浸润（LVSI）是PFS[比值比（OR）：21.37，p = 0.005]和OS[OR：8.09，p = 0.044]的独立不良预后因素。次优细胞减灭术是PFS的另一个独立不良预后因素[OR：5.68，p < 0.001]。我们的研究表明，LVSI和最佳细胞减灭术是影响晚期EC患者生存的最重要因素。
