Yilmaz M, Cimilli G, Saritemur M, Demircan F, Isaoglu U, Kisaoglu A, Emet M
a Department of Obstetrics and Gynecology , Ataturk University, Faculty of Medicine , Erzurum , Turkey.
b Department of Obstetrics and Gynecology , Nene Hatun Obstetrics and Gynecology Hospital , Erzurum , Turkey.
J Obstet Gynaecol. 2016;36(2):218-22. doi: 10.3109/01443615.2015.1049989. Epub 2015 Oct 14.
The main aim of this diagnostic case-control study of 136 patients with ovarian cysts (44 patients with ovarian torsion and 92 controls) was to determine the diagnostic value of haematologic inflammatory markers (neutrophil/lymphocyte ratio [NLR], red cell distribution width [RDW] and platelet distribution width [PDW]) for torsioned ovarian cysts. The presence of a torsioned ovarian cyst was identified by a 1.18-fold increase in the NLR (95%CI: 1.04-1.34, P = 0.009), a 1.22-fold increase in the RDW (95%CI: 1.04-1.43, P = 0.023) and a 1.93-fold increase in the PDW (95%CI: 1.19-3.14, P = 0.007). The NLR was the best predictor of a torsioned ovarian cyst (AUC: 0.74; 95% CI: 0.68-0.83). When an NLR cut-off value of 2.44 was used to determine ovarian torsion, the sensitivity, specificity, + LR and -LR were 70.5%, 70.7%, 2.40 and 0.42, respectively. In conclusion, the NLR may have diagnostic and prognostic value in determining torsioned ovarian cysts.
这项针对136例卵巢囊肿患者（44例卵巢扭转患者和92例对照）的诊断性病例对照研究的主要目的是确定血液学炎症标志物（中性粒细胞/淋巴细胞比值[NLR]、红细胞分布宽度[RDW]和血小板分布宽度[PDW]）对扭转性卵巢囊肿的诊断价值。扭转性卵巢囊肿的存在通过以下指标得以确定：NLR升高1.18倍（95%置信区间：1.04 - 1.34，P = 0.009），RDW升高1.22倍（95%置信区间：1.04 - 1.43，P = 0.023），PDW升高1.93倍（95%置信区间：1.19 - 3.14，P = 0.007）。NLR是扭转性卵巢囊肿的最佳预测指标（曲线下面积：0.74；95%置信区间：0.68 - 0.83）。当使用NLR临界值2.44来确定卵巢扭转时，敏感性、特异性、阳性似然比和阴性似然比分别为70.5%、70.7%、2.40和0.42。总之，NLR在确定扭转性卵巢囊肿方面可能具有诊断和预后价值。
