神经精神性狼疮的整合神经科学方法
Integrative neuroscience approach to neuropsychiatric lupus.
作者信息
Huerta Patricio T, Gibson Elizabeth L, Rey Carson, Huerta Tomás S
机构信息
Laboratory of Immune and Neural Networks, Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA.
Department of Molecular Medicine, Hofstra North Shore LIJ Medical School, Hempstead, NY, USA.
出版信息
Immunol Res. 2015 Dec;63(1-3):11-7. doi: 10.1007/s12026-015-8713-6.
Abstract
We present a succinct review of our approach to study the interactions between the DNA-reactive antibodies that cross-react with the GluN2A and GluN2B subunits of the N-methyl-D-aspartate receptor, denoted DNRABs, and their brain targets in subjects with neuropsychiatric systemic lupus erythematosus (NPSLE). We have analyzed the DNRAB-based brain symptomatology in mouse models of NPSLE by using an integrative neuroscience approach, which includes behavioral assessment coupled with electrophysiological studies of neural networks and synaptic connections in target brain regions, such as the CA1 region of the hippocampus. Our results suggest a framework for understanding the interactions between immune factors and neural networks.
摘要
我们简要回顾了我们的研究方法，该方法用于研究与N-甲基-D-天冬氨酸受体的GluN2A和GluN2B亚基发生交叉反应的DNA反应性抗体（称为DNRABs）与神经精神性系统性红斑狼疮（NPSLE）患者大脑靶点之间的相互作用。我们通过综合神经科学方法分析了NPSLE小鼠模型中基于DNRABs的脑症状，该方法包括行为评估以及对海马体CA1区等目标脑区神经网络和突触连接的电生理研究。我们的结果为理解免疫因子与神经网络之间的相互作用提供了一个框架。
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