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长骨感染管理的创新策略:Masquelet技术综述

Innovative strategies for the management of long bone infection: a review of the Masquelet technique.

作者信息

Chadayammuri Vivek, Hake Mark, Mauffrey Cyril

机构信息

University of Colorado School of Medicine, Aurora, CO USA.

Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI USA.

出版信息

Patient Saf Surg. 2015 Oct 14;9:32. doi: 10.1186/s13037-015-0079-0. eCollection 2015.

DOI:10.1186/s13037-015-0079-0
PMID:26468329
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4604613/
Abstract

Post-traumatic long bone osteomyelitis (PTOM) is a relatively frequent occurrence in patients with severe open fractures and requires treatment to prevent limb-threatening complications. The Masquelet technique represents a length-independent, two-staged reconstruction that involves the induction of a periosteal membrane and use of an antibiotic-impregnated cement spacer for the treatment of segmental bone loss that result from bone infection. In this review, we summarize recent developments regarding the diagnosis and treatment of long bone PTOM, with a special emphasis on the use of the Masquelet technique for reconstruction of wide diaphyseal defects.

摘要

创伤后长骨骨髓炎(PTOM)在严重开放性骨折患者中较为常见,需要进行治疗以预防危及肢体的并发症。Masquelet技术是一种与长度无关的两阶段重建方法,包括诱导骨膜形成和使用抗生素骨水泥间隔物来治疗由骨感染导致的节段性骨缺损。在本综述中,我们总结了长骨PTOM诊断和治疗的最新进展,特别强调了使用Masquelet技术重建骨干大段骨缺损。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8058/4604613/2d17399777cf/13037_2015_79_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8058/4604613/dd32e07489c7/13037_2015_79_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8058/4604613/0ee59f1a4820/13037_2015_79_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8058/4604613/a403ef77f873/13037_2015_79_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8058/4604613/f71788d3f25f/13037_2015_79_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8058/4604613/2d17399777cf/13037_2015_79_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8058/4604613/dd32e07489c7/13037_2015_79_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8058/4604613/0ee59f1a4820/13037_2015_79_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8058/4604613/a403ef77f873/13037_2015_79_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8058/4604613/f71788d3f25f/13037_2015_79_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8058/4604613/2d17399777cf/13037_2015_79_Fig5_HTML.jpg

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The masquelet induced membrane technique with BMP and a synthetic scaffold can heal a rat femoral critical size defect.采用骨形态发生蛋白(BMP)和合成支架的膜诱导技术可修复大鼠股骨临界尺寸骨缺损。
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