Bittersohl G
Z Gesamte Hyg. 1989 Jan;35(1):28-30.
Based on the present level of perception of the benzene biotransformation, the influence of reactive metabolites on the haematopoetic system - maintaining low MAK rates of 5 mg/m3 and below them - is presented. Consequences for the rate of the biological exposition test utilized at present result from this statement. The importance of a regular SCE determination in circulating lymphocytes, of the longtermed examination of possible damages of sperm and the differentiated analysis of individual kinds of lymphocytes, incl. of the cell-mediating immunity is emphasized besides the performance of a regular supervision of the external exposition, i.e. by means of personal dosimeters. To clarify the benzene influence, the research should be orientated on the damages of the cytoskeleton and the stroma cells within the haematopoetic system.
基于目前对苯生物转化的认知水平，阐述了活性代谢产物对造血系统的影响——将职业接触限值（MAK）设定为5毫克/立方米及以下。由此得出了目前所采用的生物暴露测试速率的相关结论。除了通过个人剂量计对外暴露进行定期监测外，强调了定期测定循环淋巴细胞中的姐妹染色单体互换（SCE）、长期检查精子可能的损伤以及对各类淋巴细胞进行差异化分析的重要性，包括细胞介导免疫方面的分析。为阐明苯的影响，研究应着眼于造血系统内细胞骨架和基质细胞的损伤。
