Oikkonen M, Rosenberg P H, Saarnivaara L
Department of Anesthesia, Otolaryngological Hospital, Helsinki University Central Hospital, Finland.
Acta Anaesthesiol Scand. 1989 Feb;33(2):129-31. doi: 10.1111/j.1399-6576.1989.tb02874.x.
Hepatic cytochrome-P-450-linked microsomal metabolism is inhibited by cimetidine, and to a lesser extent by ranitidine. Such an inhibition might protect against the metabolite-related toxicity of inhalation anesthetics. However, in comparison with the values measured in a control group, neither cimetidine (600 mg p.o. + 200 mg i.m.) nor ranitidine (150 mg p.o. + 50 mg i.m.), both administered 11-12 h before anesthesia, inhibited enflurane metabolism as assessed by the increase in plasma inorganic fluoride concentration and urinary fluoride excretion in 21 ASA I patients anesthetized with enflurane (end-tidal concentration 0.5 +/- 0.05% for 2-6 h). The inorganic fluoride concentration in the gastric juice remained low in all groups.
西咪替丁可抑制肝微粒体细胞色素P - 450相关的代谢过程，雷尼替丁的抑制作用相对较弱。这种抑制作用可能会预防吸入麻醉药的代谢物相关毒性。然而，与对照组所测值相比，在麻醉前11 - 12小时给予西咪替丁（口服600毫克 + 肌肉注射200毫克）或雷尼替丁（口服150毫克 + 肌肉注射50毫克），在21例接受恩氟烷麻醉（呼气末浓度0.5±0.05%，持续2 - 6小时）的美国麻醉医师协会I级患者中，通过血浆无机氟浓度升高和尿氟排泄评估，二者均未抑制恩氟烷的代谢。所有组胃液中的无机氟浓度均保持在较低水平。
