链球菌 M1 通过中和抗菌肽来攻击。

Streptococcal M1 Strikes by Neutralizing Cathelicidins.

机构信息

Department of Microbiology, Cell Biology and Tumorbiology, Karolinska Institutet, 171 77 Stockholm, Sweden; Department of Clinical Microbiology, Karolinska University Hospital, 171 76 Stockholm, Sweden.

出版信息

Cell Host Microbe. 2015 Oct 14;18(4):390-1. doi: 10.1016/j.chom.2015.10.002.

DOI:10.1016/j.chom.2015.10.002

PMID:26468741

Abstract

Virulent group A streptococci have become a serious threat, with the emergence of the hypervirulent lineage M1T1. In this issue of Cell Host & Microbe, LaRock et al. (2015), uncover a role for the streptococcal M1 protein in neutralizing a key human antimicrobial peptide, cathelicidin.

摘要

毒力较强的 A 组链球菌已经成为一个严重的威胁，其中出现了超强毒力谱系 M1T1。在本期《细胞宿主与微生物》中，LaRock 等人（2015）揭示了链球菌 M1 蛋白在中和一种关键的人类抗菌肽——防御素中的作用。