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组织病理学参数会影响耳廓瘢痕疙瘩患者的复发率吗?

Do Histopathologic Parameters Affect the Rate of Recurrence in Auricular Keloid Patients?

作者信息

Park Tae Hwan, Lee Boram, Park Ji Hae

机构信息

*Buleun Health Care Center, Incheon, Republic of Korea †Keloid Research Foundation, New York, NY ‡Department of Pathology, Samsung Medical Center §Department of Plastic and Reconstructive Surgery, Kangbuk Samsung Hospital, Seoul, Republic of Korea.

出版信息

J Craniofac Surg. 2015 Oct;26(7):e571-3. doi: 10.1097/SCS.0000000000002125.

Abstract

The purpose of this study was to describe pathologic features in patients with auricular keloids and estimate its influence on the recurrence of the keloid disease. This study was done in 38 patients reaching the pathologic diagnosis of auricular keloids from March 2012 to February 2014. All patients were female. The average age was 24.06 ± 5.03 (18-47) and patients 21 to 23 showed the highest prevalence (38.2%). The gross morphology of auricular keloids based on our previously introduced classification was pedunculated type (25 patients, 65.8%) and sessile type (13 patients, 34.2%). A detailed case history was taken for every patient with special reference to clinical parameters, such as patient age, gross morphology, and various pathologic parameters, such as margin involvement, keloidal collagen area, perivascular lymphocytic infiltration in upper dermis, perivascular lymphocytic infiltration in keloid, presence of epidermal cyst, presence of foamy histiocytes, foreign body reaction, and superficial dermal involvement. Patient demographics and pathologic characteristics were evaluated as possible risk factors for keloid recurrence. Recurrence was defined as any elevation of the scar or extension beyond the original surgical field.Of these patients, 86.8% had successful treatment of their auricular keloids, whereas 13.2% had recurrences. Based on a current study, there was no significant correlation between the clinicopathologic findings and keloid recurrence.

摘要

本研究的目的是描述耳部瘢痕疙瘩患者的病理特征,并评估其对瘢痕疙瘩疾病复发的影响。本研究对2012年3月至2014年2月间38例经病理诊断为耳部瘢痕疙瘩的患者进行。所有患者均为女性。平均年龄为24.06±5.03岁(18 - 47岁),21至23岁的患者患病率最高(38.2%)。根据我们之前介绍的分类,耳部瘢痕疙瘩的大体形态为带蒂型(25例,65.8%)和无蒂型(13例,34.2%)。对每位患者都进行了详细的病史采集,特别关注临床参数,如患者年龄、大体形态,以及各种病理参数,如边缘受累情况、瘢痕疙瘩胶原面积、真皮上层血管周围淋巴细胞浸润、瘢痕疙瘩内血管周围淋巴细胞浸润、表皮囊肿的存在、泡沫组织细胞的存在、异物反应和真皮浅层受累情况。对患者的人口统计学和病理特征进行评估,作为瘢痕疙瘩复发的可能危险因素。复发定义为瘢痕任何程度的隆起或超出原手术范围的扩展。在这些患者中,86.8%的耳部瘢痕疙瘩得到成功治疗,而13.2%出现复发。基于当前研究,临床病理结果与瘢痕疙瘩复发之间无显著相关性。

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