Liu Hongchun, Yin Wei
Department of Preventive Dentistry, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, China.
Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University.
J Periodontol. 2016 Mar;87(3):327-33. doi: 10.1902/jop.2015.150414. Epub 2015 Oct 15.
Cortex Ilicis Rotundae has antioxidant and anti-inflammatory properties. Few studies have evaluated the effects of toothpastes containing Cortex Ilicis Rotundae. This study evaluates the antiplaque and antigingivitis effects of a test toothpaste containing 0.6% Cortex Ilicis Rotundae extract in a calcium carbonate base compared with a control toothpaste without any active ingredient.
One hundred adults with a mean plaque index (PI) ≥ 1.5 and a mean gingival index (GI) ≥ 1.0 were enrolled in this randomized, double-masked, placebo-controlled clinical trial. They were assigned randomly to use a test toothpaste or a control toothpaste. At baseline, 6 weeks, and 12 weeks, they received examinations of oral hard and soft tissues, using Löe-Silness GI for gingivitis and the Turesky modification of the Quigley-Hein PI for PI. Adverse events were monitored.
When the study was completed, the test group reported lower mean GI than the control group (1.13 ± 0.22 versus 1.30 ± 0.23; P = 0.001) and lower mean PI than the control group (2.53 ± 0.5 versus 2.93 ± 0.44; P < 0.001). Compared to the baseline, the test group had reductions in GI and PI of 14.39% and 17.86%, respectively (both P < 0.001); the control group had reductions in GI and PI of 3.7% and 3.93%, respectively (both P < 0.001). No adverse events were reported during the course of the study.
The toothpaste containing 0.6% Cortex Ilicis Rotundae was effective in reducing dental plaque and gingivitis after 12 weeks of use compared with a negative control toothpaste.
地锦草具有抗氧化和抗炎特性。很少有研究评估含地锦草牙膏的效果。本研究评估了一款含有0.6%地锦草提取物的碳酸钙基测试牙膏与不含任何活性成分的对照牙膏相比的抗牙菌斑和抗牙龈炎效果。
100名平均菌斑指数（PI）≥1.5且平均牙龈指数（GI）≥1.0的成年人参与了这项随机、双盲、安慰剂对照临床试验。他们被随机分配使用测试牙膏或对照牙膏。在基线、6周和12周时，使用洛-西尔斯牙龈指数（Löe-Silness GI）评估牙龈炎，使用奎格利-海因菌斑指数（Quigley-Hein PI）的图雷斯基改良法评估PI，对他们的口腔软硬组织进行检查。监测不良事件。
研究完成时，测试组报告的平均GI低于对照组（1.13±0.22对1.30±0.23；P = 0.001），平均PI也低于对照组（2.53±0.5对2.93±0.44；P < 0.001）。与基线相比，测试组的GI和PI分别降低了14.39%和17.86%（均P < 0.001）；对照组的GI和PI分别降低了3.7%和3.93%（均P < 0.001）。研究过程中未报告不良事件。
与阴性对照牙膏相比，含0.6%地锦草的牙膏在使用12周后对减少牙菌斑和牙龈炎有效。
