[THE SERUM LEVEL OF TOTAL AND OLIGOMERIC FRACTIONS OF SOLUBLE MOLECULES CD38 UNDER MALIGNANT TUMORS OF CERVIX AND UTERINE BODY].

The immune-enzyme analysis was applied using anti-CD38 monoclonal antibodies to detect serum content of total (sCD38) and oligomeric fractions of soluble molecules CD38 (ol.sCD38) in patients with cervix cancer and malignant neoplasms of uterine body. The three- and four-fold increasing of serum level of sCD38 is demonstrated both under cervix cancer and malignant neoplasms of uterine body. The level of ol.sCD38 decreased in patients with cervix cancer and increased in case of patients with malignant neoplasms of uterine body. The serum content of ol.sCD38 was increased under adenocarcinoma of uterus and glandular epidermoid cancer. The content of sCD38 increased under adenocarcinoma of uterus but decreased under sarcoma of uterus. The highest level of soluble molecules of CD38 was established in patients with highly differentiated tumors and under invasion into endometrium but not into miometrium. On the whole, alterations in content of soluble molecules CD38 are associated with characteristics of tumor process that indicates at their monitoring significance under malignant neoplasms of uterus.