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[器官移植受者中的慢性戊型肝炎病毒感染与治疗]

[Chronic Hepatitis E Virus Infection and Treatment in Organ Transplant Recipients].

作者信息

Chen Shu, Wei Feixue, Wu Ting, Xia Ningshao

出版信息

Bing Du Xue Bao. 2015 May;31(3):293-8.

Abstract

Hepatitis E, caused by hepatitis E virus (HEV) infection, usually leads to an acute clinical course, and is the most common diagnosis among cases of acute viral hepatitis. From 2008, there have been increasing reports of chronic HEV infection in immunocompromised patients such as organ transplant recipients. Without intervention with antiviral treatment, approximately 60% of HEV infections in organ transplant recipients evolve into chronic HEV infections. Of these chronic hepatitis E patients, 10% may develop liver fibrosis and progress to liver cirrhosis. This article reviews chronic HEV infection and treatment in organ transplant recipients.

摘要

戊型肝炎由戊型肝炎病毒(HEV)感染引起,通常呈急性临床病程,是急性病毒性肝炎病例中最常见的诊断类型。自2008年以来,器官移植受者等免疫功能低下患者中慢性戊型肝炎病毒感染的报告不断增加。如果不进行抗病毒治疗干预,器官移植受者中约60%的戊型肝炎病毒感染会发展为慢性戊型肝炎病毒感染。在这些慢性戊型肝炎患者中,10%可能会发展为肝纤维化并进展为肝硬化。本文综述了器官移植受者中的慢性戊型肝炎病毒感染及治疗情况。

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