未接受过抗逆转录病毒治疗的农村艾滋病病毒感染者中艾滋病病毒逆转录酶基因突变情况

HIV reverse transcriptase gene mutations in anti-retroviral treatment naïve rural people living with HIV/AIDS.

作者信息

Mohanakrishnan K, Kasthuri A, Amsavathani S K, Sumathi G

机构信息

Department of Microbiology, Sri Muthukumaran Medical College and Research Institute, Mangadu, Chennai, Tamil Nadu, India.

出版信息

Indian J Med Microbiol. 2015 Oct-Dec;33(4):565-7. doi: 10.4103/0255-0857.167326.

DOI:10.4103/0255-0857.167326

PMID:26470965

Abstract

This study is designed to find out the mutational variations of reverse transcriptase (RT) gene of HIV, after the traditional drug usage among anti-retroviral therapy naïve rural people living with HIV/AIDS. HIV Reactive patients, who were exposed for indigenous medicines such as Siddha, Ayurveda etc., for a minimum period of 6 months were taken for this study. Among 40 patients, two samples (5.55%) demonstrated high-level mutational resistance variations for nucleoside RT inhibitor (NRTI) and non-NRTI. The predominant polymorphisms detected were K122E (91.7%), V60I (91.7%), V35T (89%), Q207E (89%), D177E (89%), T200A (86.1%), S48T (83.33%), K173A (80.6%).

摘要

本研究旨在了解在未接受过抗逆转录病毒治疗的农村艾滋病病毒感染者中，使用传统药物后艾滋病病毒逆转录酶（RT）基因的突变情况。本研究选取了至少6个月来一直使用悉达、阿育吠陀等本土药物的HIV反应性患者。在40名患者中，有两个样本（5.55%）对核苷类逆转录酶抑制剂（NRTI）和非核苷类逆转录酶抑制剂（NNRTI）表现出高水平的突变耐药性。检测到的主要多态性为K122E（91.7%）、V60I（91.7%）、V35T（89%）、Q207E（89%）、D177E（89%）、T200A（86.1%）、S48T（83.33%）、K173A（80.6%）。