Jamieson D G, Greenberg J H
Department of Neurology, University of Pennsylvania, School of Medicine, Philadelphia 19104-6063.
Comput Med Imaging Graph. 1989 Jan-Feb;13(1):61-79. doi: 10.1016/0895-6111(89)90079-7.
Positron emission tomography (PET) is a technique of transverse tomographic imaging in which detection of two photons emitted from the annihilation of a positron and an electron is used to reconstruct the distribution of a positron emitting isotope within an object. PET provides the capacity to quantitatively measure the local tissue distribution of a variety of radionuclides that are attached to compounds that distribute according to function. Although this technique has been used to measure multiple functions and receptors within the brain, one of the most widespread uses is the measurement of local cerebral glucose metabolism based on the deoxyglucose method. In this article, the application of PET to clinical disorders such as dementia, brain tumors, psychiatric disease, epilepsy, movement disorders, and stroke as well as to normal states such as aging are examined.
正电子发射断层扫描（PET）是一种横向断层成像技术，其中利用对正电子与电子湮灭时发射的两个光子的检测来重建物体内发射正电子的同位素的分布。PET能够定量测量附着于根据功能分布的化合物上的多种放射性核素的局部组织分布。尽管该技术已被用于测量脑内的多种功能和受体，但最广泛的用途之一是基于脱氧葡萄糖法测量局部脑葡萄糖代谢。在本文中，将探讨PET在痴呆、脑肿瘤、精神疾病、癫痫、运动障碍和中风等临床疾病以及衰老等正常状态中的应用。
