Brambilla Lorenzo, Pulici Luca, Carimati Giulia, Quaglia Alessandro, Prospero Emanuele, Bait Corrado, Morenghi Emanuela, Portinaro Nicola, Denti Matteo, Volpi Piero
Università degli Studi di Milano, Milano, Italy.
Humanitas Research Hospital, Rozzano, Italy.
Am J Sports Med. 2015 Dec;43(12):2966-73. doi: 10.1177/0363546515608483. Epub 2015 Oct 15.
Knee instability resulting from anterior cruciate ligament (ACL) rupture is an important risk factor for the onset of meniscal tears and cartilage injuries. A delay of the ligament reconstruction further increases this risk. There is currently no agreement on the right time for surgical ACL reconstruction.
To verify the correlation of time to ACL reconstruction, patient age, sex, and body mass index (BMI) with the prevalence of meniscal tears and cartilage injuries, as well as to identify the proper surgical timing to decrease the risk of developing associated injuries.
Cohort study; Level of evidence, 3.
The medical records of 988 patients who underwent primary ACL reconstruction between January 2010 and May 2014 were analyzed to collect data on the prevalence of meniscal tears and cartilage injuries, surgical timing, and patient sex, age, and BMI. Logistic regression was performed to estimate the association between the prevalence of intra-articular lesions and the independent variables of surgical timing, sex, age, and BMI.
The risk of developing at least an associated lesion increased by an average of 0.6% for each month of delay of surgical reconstruction. The odds ratio (OR) for developing an intra-articular lesion was 1.989 (95% CI, 1.403-2.820) in those waiting more than 12 months for ACL reconstruction. A 12-month delay for the intervention nearly doubled the risk of developing a medial meniscal tear (OR, 1.806 [95% CI, 1.317-2.475]) but did not modify the risk for the lateral meniscus (OR, 1.183 [95% CI, 0.847-1.653]). Concerning cartilage lesions, the risk after a 12-month delay increased in the medial compartment (femoral condyle: OR, 2.347 [95% CI, 1.499-3.676]; tibial plateau: OR, 5.574 [95% CI, 1.911-16.258]). In the lateral femoral condyle, the risk became significant in patients who underwent surgery more than 60 months after ACL injury as compared with those treated in the first 3 months (OR, 5.949 [95% CI, 1.825-19.385]). Lateral tibial plateau lesions did not seem to increase significantly. Male sex was a risk factor for the onset of lateral meniscal tears (OR, 2.288 [95% CI, 1.596-3.280]) and medial tears (OR, 1.752 [95% CI, 1.280-2.399]). Older age (OR, 1.017 [95% CI, 1.006-1.029]) and increased BMI (OR, 1.120 [95% CI, 1.072-1.169]) were risk factors for the occurrence of at least 1 associated lesion.
ACL reconstruction within 12 months of injury can significantly reduce the risk of meniscal tears and chondral lesions. The close association between BMI and prevalence of associated lesions suggests that attention be paid to patients with an elevated BMI when considering the timing of ACL reconstruction surgery.
前交叉韧带(ACL)断裂导致的膝关节不稳定是半月板撕裂和软骨损伤发生的重要危险因素。韧带重建的延迟会进一步增加这种风险。目前对于ACL重建手术的合适时机尚无定论。
验证ACL重建时间、患者年龄、性别和体重指数(BMI)与半月板撕裂和软骨损伤发生率之间的相关性,并确定适当的手术时机以降低发生相关损伤的风险。
队列研究;证据等级,3级。
分析2010年1月至2014年5月期间接受初次ACL重建的988例患者的病历,收集半月板撕裂和软骨损伤发生率、手术时机以及患者性别、年龄和BMI的数据。进行逻辑回归分析以评估关节内病变发生率与手术时机、性别、年龄和BMI等自变量之间的关联。
手术重建每延迟一个月,发生至少一种相关病变的风险平均增加0.6%。等待ACL重建超过12个月的患者发生关节内病变的比值比(OR)为1.989(95%可信区间,1.403 - 2.820)。干预延迟12个月使内侧半月板撕裂的风险几乎翻倍(OR,1.806 [95%可信区间,1.317 - 2.475]),但未改变外侧半月板的风险(OR,1.183 [95%可信区间,0.847 - 1.653])。关于软骨病变,延迟12个月后内侧间室(股骨髁:OR,2.347 [95%可信区间,1.499 - 3.676];胫骨平台:OR,5.574 [95%可信区间,1.911 - 16.258])的风险增加。在外侧股骨髁,与伤后前3个月接受治疗的患者相比,ACL损伤后60个月以上接受手术的患者风险显著增加(OR,5.949 [95%可信区间,1.825 - 19.385])。外侧胫骨平台病变似乎没有显著增加。男性是外侧半月板撕裂(OR,2.288 [95%可信区间,1.596 - 3.280])和内侧撕裂(OR,1.752 [95%可信区间,1.280 - 2.399])发生的危险因素。年龄较大(OR,1.017 [95%可信区间,1.006 - 1.029])和BMI增加(OR,1.120 [95%可信区间,1.072 - 1.169])是发生至少一种相关病变的危险因素。
伤后12个月内进行ACL重建可显著降低半月板撕裂和软骨损伤的风险。BMI与相关病变发生率之间的密切关联表明,在考虑ACL重建手术时机时应关注BMI升高的患者。