Newsome Y L, Singh D N
Acta Cytol. 1977 Jan-Feb;21(1):137-40.
Preliminary data show adriamycin (AM) induces chromosomal structural changes and division delay in human peripheral lymphocytes. Cells treated for one hour with 0.01, 0.03, 0.05 and 0.10 mug/ml AM show chromatid lesions mainly breaks and deletions. Chromosome type lesions and chromatid exchanges were less frequent even in cells with the highest percentage of aberrations. Dicentric chromosomes were very rare and were scored only in cells treated with higher concentrations (0.10 mug/ml) and recovered 24 hour post-treatment. Based solely on cytologic evidence G1 and S phase cells appear to be more sensitive to adriamycin than G2 phase cells.
初步数据显示，阿霉素（AM）可诱导人外周血淋巴细胞发生染色体结构变化和分裂延迟。用0.01、0.03、0.05和0.10微克/毫升的阿霉素处理细胞1小时后，可见染色单体损伤，主要为断裂和缺失。即使在畸变率最高的细胞中，染色体型损伤和染色单体交换也较少见。双着丝粒染色体非常罕见，仅在接受较高浓度（0.10微克/毫升）处理并在处理后24小时恢复的细胞中观察到。仅基于细胞学证据，G1期和S期细胞似乎比G2期细胞对阿霉素更敏感。
