Krishan A, Frei E
Cancer Res. 1976 Jan;36(1):143-50.
Exposure of cultured human lymphoblasts to adriamycin (ADM) (0.1 mug/ml for 24 hr or 0.5 mug/ml for 1 hr) leads to an accumulation of cells with the DNA content of late S and G2. Higher concentrations of ADM (0.5 to 10 mug/ml) inhibit cell cycle traverse. Effect of ADM on cell cycle traverse, cell growth, and incorporation of labeled precursors into DNA is dependent on drug concentration and length of exposure to ADM. Synchronized cells in G1 or G2 part of the cell cycle are less sensitive to ADM than cells in S phase. Similarly, plateau-phase cells are less sensitive to ADM than cells from log-phase cultures.
将培养的人淋巴母细胞暴露于阿霉素（ADM）（0.1μg/ml处理24小时或0.5μg/ml处理1小时）会导致具有晚S期和G2期DNA含量的细胞积累。更高浓度的ADM（0.5至10μg/ml）会抑制细胞周期进程。ADM对细胞周期进程、细胞生长以及标记前体掺入DNA的影响取决于药物浓度和暴露于ADM的时间长度。处于细胞周期G1或G2期的同步化细胞对ADM的敏感性低于S期细胞。同样，平台期细胞对ADM的敏感性低于对数期培养的细胞。
