Verne Sebastian H, Kennedy Johnathan, Falto-Aizpurua Leyre A, Griffith Robert D, Nouri Keyvan
Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
Int J Dermatol. 2016 Apr;55(4):376-81. doi: 10.1111/ijd.13069. Epub 2015 Oct 16.
Granuloma annulare (GA) is a benign asymptomatic dermatosis that typically manifests in papules arrayed in annular arrangements. Many methods of treatment have been used with variable degrees of success, but finding a consistent and long-term treatment has proven a challenge. This study was conducted in order to review and evaluate the latest published research on the use of lasers in the treatment of GA. A systematic search of the National Library of Medicine's PubMed database was performed to identify relevant articles. Seven reports met the inclusion criteria for the review. Evidence for the use of pulsed dye laser, fractional photothermolysis, and excimer laser in the treatment of GA was found. Findings are limited by a lack of well-designed clinical trials objectively evaluating the use of lasers in the treatment of GA. The literature review found a number of case reports and case series that report successful outcomes of the use of lasers in the treatment of GA. The promising results reported in the literature, coupled with the lack of a well-designed review on this topic, reflect the importance of this article to the dermatologic literature as it emphasizes the need for larger and better-designed studies on the use of lasers to treat GA.
环状肉芽肿(GA)是一种良性无症状性皮肤病,通常表现为呈环状排列的丘疹。许多治疗方法都曾被使用,且取得了不同程度的成功,但找到一种持续有效的长期治疗方法已被证明是一项挑战。开展这项研究是为了回顾和评估关于使用激光治疗GA的最新发表研究。对美国国立医学图书馆的PubMed数据库进行了系统检索,以识别相关文章。七篇报告符合该综述的纳入标准。发现了使用脉冲染料激光、非剥脱性光热解和准分子激光治疗GA的证据。研究结果受到缺乏客观评估激光治疗GA效果的精心设计的临床试验的限制。文献综述发现了一些病例报告和病例系列,报告了使用激光治疗GA取得成功的结果。文献中报道的有前景的结果,再加上缺乏关于该主题的精心设计的综述,反映了本文对皮肤科文献的重要性,因为它强调了需要开展更大规模、设计更优的研究来探讨使用激光治疗GA。