对BC3H-1肌细胞中体内磷酸化蛋白的研究表明，蛋白激酶C参与胰岛素作用。
Studies of in vivo phosphorylated proteins in BC3H-1 myocytes suggest that protein kinase C is involved in insulin action.
作者信息
Vila M C, Cooper D R, Davis J S, Standaert M L, Farese R V
机构信息
Veterans Administration Hospital, Tampa, FL.
出版信息
FEBS Lett. 1989 Feb 13;244(1):177-80. doi: 10.1016/0014-5793(89)81187-1.
PMID:2647517
Abstract
Insulin (10 and 100 nM) and phorbol esters increased the phosphorylation of several proteins, including 40, 47 and 80 kDa proteins, which are markers for protein kinase C activation. Insulin effects were evident at 2 min and increased over 20 min. These findings suggest that insulin activates protein kinase C in BC3H-1 myocytes.
摘要
胰岛素（10和100纳摩尔）以及佛波酯增加了几种蛋白质的磷酸化，包括40、47和80千道尔顿的蛋白质，这些是蛋白激酶C激活的标志物。胰岛素的作用在2分钟时就很明显，并在20分钟内增强。这些发现表明胰岛素在BC3H-1肌细胞中激活了蛋白激酶C。
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