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本文引用的文献

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Drug-induced gingival overgrowth: The nemesis of gingiva unravelled.药物性牙龈增生:牙龈病变之谜揭晓。
J Indian Soc Periodontol. 2013 Mar;17(2):182-7. doi: 10.4103/0972-124X.113066.
2
Idiopathic gingival hyperplasia: a case report with a 17-year followup.特发性牙龈增生:一例随访17年的病例报告
Case Rep Dent. 2011;2011:986237. doi: 10.1155/2011/986237. Epub 2011 Jul 3.
3
Phenytoin-induced gingival overgrowth: a review of the molecular, immune, and inflammatory features.苯妥英钠所致牙龈增生:分子、免疫及炎症特征综述
ISRN Dent. 2011;2011:497850. doi: 10.5402/2011/497850. Epub 2011 Jul 25.
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Idiopathic gingival fibromatosis associated with generalized aggressive periodontitis: a case report.与广泛侵袭性牙周炎相关的特发性牙龈纤维瘤病:一例报告
J Can Dent Assoc. 2009 May;75(4):291-5.
5
Efficacy of AZM therapy in patients with gingival overgrowth induced by Cyclosporine A: a systematic review.阿奇霉素治疗环孢素A诱导的牙龈过度生长患者的疗效:一项系统评价
BMC Oral Health. 2008 Dec 16;8:34. doi: 10.1186/1472-6831-8-34.
6
Morphological and molecular analysis of idiopathic gingival fibromatosis: a case report.特发性牙龈纤维瘤病的形态学和分子分析:一例报告
J Clin Periodontol. 2005 Oct;32(10):1116-21. doi: 10.1111/j.1600-051X.2005.00811.x.
7
Drug-associated gingival enlargement.药物性牙龈增生
J Periodontol. 2004 Oct;75(10):1424-31. doi: 10.1902/jop.2004.75.10.1424.
8
Prophylactic Anticonvulsants After Neurosurgery.神经外科手术后的预防性抗惊厥药物
Epilepsy Curr. 2002 Jul;2(4):105-107. doi: 10.1111/j.1535-7597.2002.00038.x.
9
Treatment of drug-induced gingival enlargement: aesthetic and functional considerations.药物性牙龈肥大的治疗:美学与功能考量
Periodontol 2000. 2001;27:131-8. doi: 10.1034/j.1600-0757.2001.027001131.x.
10
The Brain Trauma Foundation. The American Association of Neurological Surgeons. The Joint Section on Neurotrauma and Critical Care. Role of antiseizure prophylaxis following head injury.脑创伤基金会。美国神经外科医师协会。神经创伤与重症监护联合分会。头部损伤后预防性抗癫痫治疗的作用。
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苯妥英钠在神经外科患者中一种广为人知且重要的不良反应。

A well known and important adverse effect of phenytoin in a neurosurgical patient.

作者信息

Tomar Gaurav Singh, Saxena Anudeep, Kumar Niraj, Goyal Keshav

机构信息

Department of Neuroanaesthesiology and Critical Care, JPNA Trauma Centre, All India Institute of Medical Sciences, New Delhi, India.

Department of Anaesthesiology and Critical Care, JPNA Trauma Centre, All India Institute of Medical Sciences, New Delhi, India.

出版信息

BMJ Case Rep. 2015 Oct 16;2015:bcr2015212227. doi: 10.1136/bcr-2015-212227.

DOI:10.1136/bcr-2015-212227
PMID:26475882
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4611416/
Abstract

Gum hypertrophy is a well-known and important adverse effect of phenytoin therapy in a neurosurgical patient. We present an interesting case of a 21-year-old man who, following head injury after a road traffic accident, developed status epilepticus diagnosed with gum hypertrophy in the jaws, with ongoing antiepileptics. He was managed conservatively as per hospital protocol.

摘要

牙龈增生是神经外科患者接受苯妥英治疗时一种众所周知且重要的不良反应。我们报告了一例有趣的病例,一名21岁男性在道路交通事故后头部受伤,随后发生癫痫持续状态,诊断为颌部牙龈增生,且正在接受抗癫痫药物治疗。按照医院规程对他进行了保守治疗。