Zand Ramin, Male Shailesh, Lynch John K
Section on Stroke Diagnostics and Therapeutics, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland.
Department of Neurology, University of Tennessee Health Science Center, Memphis, Tennessee.
J Stroke Cerebrovasc Dis. 2015 Dec;24(12):e1-3. doi: 10.1016/j.jstrokecerebrovasdis.2015.08.021. Epub 2015 Oct 21.
Transient cortical blindness (TCB) is a relatively rare but well-recognized complication following cardiovascular and cerebral angiography.
A 68-year-old male developed TCB following cerebral angiography along with punctate diffusion lesion evident on emergent magnetic resonance imaging (MRI). The patient received intravenous tissue plasminogen activator (IV-tPA) for suspected stroke.
Follow-up MRI revealed diffuse hyperintensities in subarachnoid space in fluid-attenuated inversion recovery (FLAIR) sequence mostly in bilateral occipital lobes.
The finding on the FLAIR as described in this case is an indication of diffuse disruption of the blood-brain barrier perhaps secondary to cerebral angiography, high blood pressure, and IV-tPA. To the best of our knowledge, this is the first reported case of TCB with diffuse postcontrast FLAIR changes.