Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Psychiatry, Changhua Christian Hospital, Changhua, Taiwan.
Department of Psychiatry, Chung Shan Medical University Hospital, Taichung, Taiwan; School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Psychiatry Res. 2015 Dec 15;230(2):575-80. doi: 10.1016/j.psychres.2015.10.006. Epub 2015 Oct 9.
In this prospective study, we investigated the effects of antidepressant therapy on total antioxidant capacity and free radical levels in patients with major depressive disorder (MDD). We recruited thirty-five first-episode patients who met the criteria of the Fourth Edition of Diagnostic and Statistical Manual of Mental Disorders of MDD and 35 age- and sex-matched healthy controls. Superoxide and hydroxyl radicals were measured to investigate oxidative status and the total radical-trapping antioxidant parameter (TRAP) assay was performed to evaluate antioxidant capacity in healthy controls and in patients before and after receiving a 12-week regimen of sertraline. The severity of depression was evaluated using the 17-item Hamilton Depression Rating Scale (HDRS). Before treatment, the mean HDRS score in patients with MDD was 26.11±4.93. Of the 35 patients with MDD, 19 (54.29%) completed the 12-week treatment regimen and all achieved remission. Patients with MDD had significantly lower TRAP baseline values than healthy controls. After adjusting for age, sex, occupation, education and marital status, we found that HDRS score was negatively correlated with TRAP value and level of superoxide radicals. After treatment, the MDD group demonstrated significantly higher TRAP values and significantly lower levels of superoxide and hydroxyl radicals. In conclusion, MDD patients are accompanied by lowered antioxidant capacity than healthy individuals. Antidepressant treatment for 12 weeks results in increased antioxidant capacity and a decrease in circulating free radicals.
在这项前瞻性研究中，我们调查了抗抑郁治疗对伴有重度抑郁症（MDD）的患者总抗氧化能力和自由基水平的影响。我们招募了 35 名符合《精神障碍诊断与统计手册》第四版（DSM-IV）MDD 标准的首发患者和 35 名年龄和性别匹配的健康对照者。我们测量超氧自由基和羟自由基以研究氧化状态，并用总自由基捕获抗氧化参数（TRAP）测定法评估健康对照组和接受为期 12 周舍曲林治疗前后的患者的抗氧化能力。用 17 项汉密尔顿抑郁评定量表（HDRS）评估抑郁严重程度。在治疗前，MDD 患者的平均 HDRS 评分是 26.11±4.93。35 名 MDD 患者中，19 名（54.29%）完成了 12 周的治疗方案，所有患者均达到缓解。MDD 患者的 TRAP 基线值明显低于健康对照组。在调整年龄、性别、职业、教育和婚姻状况后，我们发现 HDRS 评分与 TRAP 值和超氧自由基水平呈负相关。治疗后，MDD 组的 TRAP 值明显升高，超氧自由基和羟自由基水平明显降低。总之，MDD 患者的抗氧化能力低于健康个体。抗抑郁治疗 12 周可增加抗氧化能力并减少循环自由基。
