镰状细胞贫血青少年慢性难治性腿部溃疡的成功管理

Successful Management of a Chronic Refractory Leg Ulcer in an Adolescent with Sickle Cell Anemia.

作者信息

Paolino Giovanni, Santopietro Michelina, Palumbo Giovanna, Onesti Maria Giuseppina, Micozzi Alessandra, Venosi Salvatore, Laurino Marica, Ferrazza Giancarlo, Fino Pasquale, Foà Robin, Giona Fiorina

机构信息

Giovanni Paolino, MD, Clinica Dermatologica, La Sapienza University of Rome, Viale del Policlinico 15, 00186 Rome, Italy;

出版信息

Acta Dermatovenerol Croat. 2015;23(3):213-7.

PMID:26476907

Abstract

Sickle cell disease (SCD) is an inherited hemoglobinopathy characterized by a wide range of clinical manifestations. Chronic leg ulcers are a disabling complication with repercussions on the quality of life. We report the case of a 14-year-old girl with a diagnosis of SCD who developed a chronic leg ulcer that was successfully treated with a multi-disciplinary approach, including local and systemic therapies. The role of different treatments, in particular low molecular weight heparin, in the refractory chronic leg ulcer healing process will be discussed.

摘要

镰状细胞病（SCD）是一种遗传性血红蛋白病，具有广泛的临床表现。慢性腿部溃疡是一种致残性并发症，会对生活质量产生影响。我们报告一例14岁诊断为SCD的女孩，她出现了慢性腿部溃疡，通过包括局部和全身治疗在内的多学科方法成功治愈。将讨论不同治疗方法，特别是低分子量肝素，在难治性慢性腿部溃疡愈合过程中的作用。