将药物靶向胶质瘤和实体瘤中枢神经系统转移灶的策略。
Strategies to target drugs to gliomas and CNS metastases of solid tumors.
作者信息
Milojkovic Kerklaan B, van Tellingen O, Huitema A D R, Beijnen J H, Boogerd W, Schellens J H M, Brandsma D
机构信息
Department of Molecular Pathology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam, The Netherlands.
Department of Clinical Pharmacology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam, The Netherlands.
出版信息
J Neurol. 2016 Mar;263(3):428-40. doi: 10.1007/s00415-015-7919-9. Epub 2015 Oct 17.
The treatment for central nervous system metastases of solid tumors and gliomas is limited as the blood-brain barrier (BBB) is an obstacle to systemic therapy. Here, we review the physiochemical properties of the BBB and both current and new drug strategies to penetrate brain tumors. We focus on targeting receptor- or carrier-mediated transport mechanisms over the BBB used by drug conjugates, nanoparticles, polymer-based nanocarriers, siRNA, and antibodies.
实体瘤和神经胶质瘤的中枢神经系统转移瘤的治疗方法有限，因为血脑屏障（BBB）是全身治疗的障碍。在此，我们综述血脑屏障的物理化学特性以及目前和新的穿透脑肿瘤的药物策略。我们重点关注药物偶联物、纳米颗粒、聚合物基纳米载体、小干扰RNA（siRNA）和抗体利用的靶向血脑屏障上受体介导或载体介导的转运机制。
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