Yamada K, Ushio Y, Hayakawa T, Kato A, Yamada N, Mogami H
J Neurosurg. 1982 Sep;57(3):394-8. doi: 10.3171/jns.1982.57.3.0394.
Quantitative autoradiographic technique was applied in measuring blood-brain barrier (BBB) permeability of autochthonous gliomas in rats. In small tumors (less than 2 mm in diameter), no increase in BBB permeability was noted. As the tumor grew and neovascularization occurred, BBB permeability increased in the center of the tumor, and it was suggested that the BBB was partly disrupted in the neovascularized vessels. In the fully grown tumors, BBB permeability was markedly increased in the viable part of the tumor to levels similar to the choroid plexus. Yet, the BBB was partly preserved at the periphery of the tumor and in the brain adjacent to the tumor. The heterogeneity of the BBB phenomenon according to the stage of tumor growth may be a major obstacle for uptake of chemotherapeutic drugs that do not cross the BBB easily.
采用定量放射自显影技术测量大鼠原位胶质瘤的血脑屏障（BBB）通透性。在小肿瘤（直径小于2毫米）中，未观察到血脑屏障通透性增加。随着肿瘤生长和新血管形成，肿瘤中心的血脑屏障通透性增加，提示新生血管中的血脑屏障部分被破坏。在完全生长的肿瘤中，肿瘤存活部分的血脑屏障通透性显著增加，达到与脉络丛相似的水平。然而，肿瘤周边和肿瘤相邻脑区的血脑屏障部分保留。血脑屏障现象根据肿瘤生长阶段的异质性可能是不易穿过血脑屏障的化疗药物摄取的主要障碍。
