Chen L T, Handler E E
Anat Rec. 1977 Jan;187(1):29-46. doi: 10.1002/ar.1091870104.
The spleens of rats were studied by light and electron microscopy during the course of an acute myelogenous leukemia, with special reference to infiltration of leukemic myeloblasts in the spleens and to the correlation of leukemic cell infiltration with splenic hematopoiesis and splenomegaly. Leukemic myeloblasts infiltrated the cordal space of the red pulp. Many of them appeared in groups. Even in spleens which were heavily infiltrated, leukemic myeloblasts did not penetrate the while pulp. Massive infiltration and proliferation of the leukemic myeloblasts in the red pulp resulted in splenomegaly. The spleen increased its hematopoietic activity, while the medullary hematopoiesis diminished due to the invasion of leukemic myeloblasts in the bone marrow. Compensatory splenic hematopoiesis occurred in most of the leukemic spleens, but diminished in spleens which were very heavily infiltrated with leukemic myeloblasts. Thus, the degree of splenomegaly and splenic hematopoiesis did not necessarily correspond to the percentage of leukemic myeloblasts in the bone marrow, but rather related to the number of leukemic myeloblasts present in the spleen. A possible role for the splenic sinus walls in promoting compensatory hematopoiesis in the spleen is discussed. A consistent association of type "C" virus particles with leukemic myeloblasts was observed.
在急性髓性白血病病程中，对大鼠脾脏进行了光镜和电镜研究，特别关注白血病原始粒细胞在脾脏中的浸润情况，以及白血病细胞浸润与脾脏造血和脾肿大之间的相关性。白血病原始粒细胞浸润红髓的索状间隙。其中许多呈簇状出现。即使在浸润严重的脾脏中，白血病原始粒细胞也未穿透白髓。红髓中白血病原始粒细胞的大量浸润和增殖导致脾肿大。脾脏的造血活性增强，而由于白血病原始粒细胞侵入骨髓，骨髓造血减少。大多数白血病脾脏中发生了代偿性脾造血，但在白血病原始粒细胞浸润非常严重的脾脏中代偿性脾造血减少。因此，脾肿大和脾造血的程度不一定与骨髓中白血病原始粒细胞的百分比相对应，而是与脾脏中存在的白血病原始粒细胞数量有关。讨论了脾窦壁在促进脾脏代偿性造血中的可能作用。观察到“C”型病毒颗粒与白血病原始粒细胞始终相关联。
