Rinaldi M G
Fungus Testing Laboratory, Department of Pathology, University of Texas Health Science Center San Antonio.
Infect Dis Clin North Am. 1989 Mar;3(1):19-41.
Zygomycosis represents an excellent example of an opportunistic fungal infection that generally occurs in the debilitated, immunocompromised, or acidotic host. Infections are usually fulminant, with etiologic agents exhibiting predilection for invasion of blood vessels with resultant infarction and necrosis. The spectrum of agents capable of inciding zygomycosis has broadened and the incidence has increased in contemporary medicine. Nevertheless, an increased index of suspicion, better mycological acumen, aggressive surgical debridement of diseased tissue, and prompt therapy with amphotericin B have rendered substantial improvement in the prognosis of an otherwise fatal infectious disease. Rapid and accurate diagnostic techniques and the availability of less toxic, efficacious antifungal agents should be sought after goals for the enhanced management of zygomycosis.
接合菌病是机会性真菌感染的一个典型例子，通常发生在身体虚弱、免疫功能低下或酸中毒的宿主身上。感染通常呈暴发性，病原体倾向于侵入血管，导致梗死和坏死。在当代医学中，能够引发接合菌病的病原体范围已经扩大，发病率也有所增加。然而，提高怀疑指数、增强真菌学诊断能力、积极手术清除病变组织以及及时使用两性霉素B进行治疗，已使这种原本致命的传染病的预后有了显著改善。快速准确的诊断技术以及毒性较小、疗效显著的抗真菌药物的可获得性，应该成为加强接合菌病管理的追求目标。
