癸酸诺龙给药对大鼠血脂和肝酶的影响。
Influence of nandrolone decanoate administration on serum lipids and liver enzymes in rats.
作者信息
Samieinasab Mohammad Reza, Shahraki Mohammad Reza, Samieinasab Fatemah, Najafi Somayeh
机构信息
Assistant Professor, Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Associate Professor, Department of Physiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
出版信息
ARYA Atheroscler. 2015 Jul;11(4):256-60.
BACKGROUND
Anabolic-androgenic steroids have been associated with several side effects range. This experimental study was conducted to evaluate the effects of nandrolone decanoate (ND, an anabolic steroid) on lipid profile and liver enzymes in rats in Iran.
METHODS
Forty adult male and female of Wistar strain rats were randomly assigned to four groups of 10 animals each: male control, female control, ND-male treated (15 mg/kg b.w./day), and ND-female treated (15 mg/kg b.w./day). Serum concentrations of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were measured in all studied groups.
RESULTS
Treating rats with ND (case group) resulted in a significant elevation of TC (69.4 ± 8.7), TG (101.6 ± 32.9) and ALT (72.2 ± 13.8) and significant reduction of LDL (6.4 ± 2.6) and AST (138.7 ± 19.4) as compared to control group in female rats. ND supplementation (case group) significantly increased TC (64.4 ± 6.2), AST (255.0 ± 32.0), and ALT (84.3 ± 3.8) in comparison with the control group in male rats.
CONCLUSION
Overall, our result indicated that the ND use can cause a negative effect on lipid profile and liver enzyme in rats.
背景
合成代谢雄激素类固醇与多种副作用相关。本实验研究旨在评估癸酸诺龙（ND，一种合成代谢类固醇）对伊朗大鼠血脂谱和肝酶的影响。
方法
将40只成年Wistar品系大鼠随机分为四组，每组10只动物：雄性对照组、雌性对照组、接受ND治疗的雄性组（15毫克/千克体重/天）和接受ND治疗的雌性组（15毫克/千克体重/天）。测量所有研究组血清中总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇、天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）的浓度。
结果
与雌性大鼠对照组相比，用ND治疗大鼠（病例组）导致TC（69.4±8.7）、TG（101.6±32.9）和ALT（72.2±13.8）显著升高，LDL（6.4±2.6）和AST（138.7±19.4）显著降低。与雄性大鼠对照组相比，补充ND（病例组）使TC（64.4±6.2）、AST（255.0±32.0）和ALT（84.3±3.8）显著增加。
结论
总体而言，我们的结果表明，使用ND会对大鼠的血脂谱和肝酶产生负面影响。
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