从繁殖场转移至研究设施对大鼠福利的影响。

Effects of Transfer from Breeding to Research Facility on the Welfare of Rats.

作者信息

Arts Johanna W M, Oosterhuis Nynke R, Kramer Klaas, Ohl Frauke

机构信息

Department of Animals in Science & Society, Division of Animal Welfare & Laboratory Animal Science, Veterinary Faculty, Utrecht University, Utrecht, 3584 CM, The Netherlands.

Harlan Laboratories B.V., P.O. Box 553, Venray, 5800 AN, The Netherlands.

出版信息

Animals (Basel). 2014 Dec 3;4(4):712-28. doi: 10.3390/ani4040712.

DOI:10.3390/ani4040712

PMID:26479008

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4494421/

Abstract

Transfer from the breeding facility to a research facility is a stressful event for laboratory animals. Heat stress has been reported to constitute one of the major concerns during transport of animals. This study measured ambient and body temperature, corticosterone and glucose levels, body weight, behavior and water and food intake before, during and after transfer in Wistar rats. Decreased body weight, water and food intake were observed on the day of transfer in rats. Environmental temperature strongly affected body temperature of rats and needs to be controlled. Male rats need to habituate for at least one week, females for two weeks after transfer.

摘要

从繁育设施转移到研究设施对实验动物来说是一个压力事件。据报道，热应激是动物运输期间的主要问题之一。本研究测量了Wistar大鼠在转移前、转移期间和转移后的环境温度和体温、皮质酮和葡萄糖水平、体重、行为以及水和食物摄入量。在转移当天观察到大鼠体重、水和食物摄入量下降。环境温度对大鼠体温有强烈影响，需要加以控制。雄性大鼠转移后需要至少一周的适应期，雌性大鼠需要两周。