Ma Rui-ting, Huang Hui, Yan Yue-rong, Chen Da-wei, Liu Ying, Zhang Guo-fu
Sichuan Da Xue Xue Bao Yi Xue Ban. 2015 Jul;46(4):611-4.
To explore the influences of age, gender and season on serum thyroid stimulating hormone level and thyroid hormone level in healthy people.
There were 2 564 healthy volunteers enrolled in this study, whom were divided into different groups according to gender, age and the season. The levels of serum TSH, T3, T4, FT3, FT4 were measured and the data were statistically analyzed.
The level of serum TSH in both young and middle-age groups of female was higher than that in the same age groups of male. The serum levels of T3, FT3, FT4 in both young and middle-age groups of female were lower than those in the same age groups of male (P < 0.05). In female, the serum level of TSH was increasing with age. However, the serum levels of FT3, FT4 had the opposite tendency. The level of serum FT3 in young group was higher than that in elderly group of, but T4 were lower. Lower levels of TSH, T3, FT4 were found in summer instead of winter (P < 0.05) and there was no significant difference of FT3 between that two seasons. The levels of serum TSH, T3, T4 and FT4 were correlated with seasons (r = 0.079, 0.092,-0.137, 0.140).
The levels of serum TSH and thyroid hormones are influenced by age, gender and seasons, which needs to be considered for the diagnosis of thyroid diseases and evaluation of thyroid function.
探讨年龄、性别和季节对健康人血清促甲状腺激素水平和甲状腺激素水平的影响。
本研究纳入2564名健康志愿者，根据性别、年龄和季节将他们分为不同组。检测血清促甲状腺激素（TSH）、三碘甲状腺原氨酸（T3）、甲状腺素（T4）、游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）水平，并对数据进行统计学分析。
女性青年组和中年组的血清TSH水平高于同龄男性组。女性青年组和中年组的血清T3、FT3、FT4水平低于同龄男性组（P<0.05）。在女性中，血清TSH水平随年龄增长而升高。然而，血清FT3、FT4水平则呈相反趋势。青年组的血清FT3水平高于老年组，但T4水平低于老年组。夏季的TSH、T3、FT4水平低于冬季（P<0.05），两个季节的FT3水平无显著差异。血清TSH、T3、T4和FT4水平与季节相关（r=0.079、0.092、-0.137、0.140）。
血清TSH和甲状腺激素水平受年龄、性别和季节的影响，在甲状腺疾病的诊断和甲状腺功能评估中需要考虑这些因素。
